The Pakistani rupee registered significant gain against the US dollar, appreciating 0.07% during the opening hours of trading in the inter-bank market on Friday. At 10:20am, the local currency was hovering at 280.90, up by Re0.21 against the US dollar. On Thursday, the local unit closed at 281.11, according to the State Bank of Pakistan (SBP). Globally, the US dollar remained on the back